Mis diagnosed as Fibromyalgia, ME/CFS, Musculoskeletal Disease,Poly Myalgia Rheumatica - significantly improved when treated for Lyme Disease.
Perhaps more aptly described as Multi-Systemic Infectious Disease Syndrome - MSIDS.
Green fluorescent Borrelia interacting with the walls of a skin postcapillary venule of a live mice after injection of bacteria into the blood stream. Blood vessel walls are stained with a red dye. Posted by lab of Tara Moriarty (http://moriartylab.org). From: Norman et al 2008:http://journals.plos.org/plospathogen...
Fascinating research from the Moriatry Lab which has just published the following paper
Biomechanics of Borrelia burgdorferi Vascular Interactions
Rhodaba Ebady, Alexandra F. Niddam Anna E. Boczula Yae Ram Kim Nupur Gupta Tian Tian Tang Tanya Odisho
Hui Zhi Craig A. Simmons Jon T. Skare Tara J. Moriarty
•Conserved vascular interaction strategies in bacteria and host cells
Systemic dissemination of microbes is critical for progression of many infectious diseases and is associated with most mortality due to bacterial infection. The physical mechanisms mediating a key dissemination step, bacterial association with vascular endothelia in blood vessels, remain unknown. Here, we show that endothelial interactions of the Lyme disease spirochete Borrelia burgdorferi under physiological shear stress mechanistically resemble selectin-dependent leukocyte rolling etc... ................................................
These findings provide insight into the biomechanics of bacterial-vascular interactions and demonstrate that disseminating bacteria and circulating host immune cells share widely conserved mechanisms for interacting with endothelia under physiological shear stress. To read the paper go tohttp://www.cell.com/cell-reports/abstract/S2211-1247(16)31059-2
This paper is causing a great stir in the media rocketting the paper up to -
CURRENTLY IN TOP 1% OF ALL RESEARCH OUTPUTS EVER TRACKED BY ALTMETRIC
top 2% of all research papers of same age
top 4% of Cell Reports papers of same age
top 3% of all Cell Reports papers ever!!!!!
with a growing list of media interest that can be read from